Diagnostic procedures

Which diagnostic tests are used to diagnose cancer?

This page was reviewed under ourmedical and editorial policyby

马里兰州Maurie神枪手, President, Medicine & Science.

This page was updated on April 29, 2022.

Unlikediagnostic imaging tests, which are generally non-invasive or only minimally invasive, diagnostic procedures used to screen for diseases like cancer usually involve an analysis of tissue or blood, often from a biopsy.

在城市的希望,用于诊断程序cancer include those listed below.


During a biopsy, a doctor removes a sample of tissue or fluid from the body. A pathologist inspects the cells under a microscope to determine whether they are cancerous. If the cells are found to be cancerous, a biopsy may help determine whether the cancer began at the site of the biopsy or if it started somewhere else in the body and spread to the biopsy site.

Sentinel lymph node biopsy:This procedure is performed to see whether cancer has spread to thelymph nodes. First, your doctor performs a procedure known as lymph node mapping to identify which lymph nodes to remove. A blue radioactive dye is injected into the area where cancer is present. Sentinel lymph nodes usually absorb the dye after about an hour. At this point, your surgeon removes any that have turned blue and send them to the laboratory for examination. This is called an excisional biopsy.

Bone marrow biopsy:This cancer diagnostic test involves the removal of bone marrow with a long needle that enters the skin, passes through the muscle and extracts a sample from your bone. A bone marrow biopsy helps your cancer care team determine how well treatments for blood cancers likeleukemia,lymphomaormultiple myelomaare working, as well as whether the cancer has spread.

Fine-needle aspiration:This type of biopsy uses a very fine, hollow needle that is connected to a syringe to remove a very small portion of tissue or fluid from your tumor in order to detect cancer.

Core needle biopsy:Using a needle that is a bit larger than that of a fine-needle aspiration, a cylinder of tissue is removed (about 1/16 inch in diameter and 1/2 inch in length) while you’re under local anesthesia.

Learn more about biopsies


Bronchoscopy technology is used to diagnose and stage certain cancers, such as lung cancer and esophageal cancer.

Learn more about bronchoscopy

Cytology tests

Acytology testexamines cells through body fluids and tissues. These tests may be used to look for cancer when a patient is due for a regular screening or is experiencing symptoms.

For example, a urine cytology test may help diagnose urinary tract cancers, such as those of the:

Cytology tests include lumbar punctures and Pap smears.

Lumbar puncture

A lumbar puncture, or spinal tap, is a procedure during which a needle is inserted into the lower part of the spinal column to remove a sample of cerebrospinal fluid. The fluid surrounds and protects the brain and spinal cord.

A lumbar puncture is performed to collect and test the cerebrospinal fluid for diseases, infections and conditions that affect the central nervous system, including:

  • Meningitis
  • Cancer (e.g., brain cancer, spinal cancer, leukemia)
  • Bleeding around the brain or spinal cord
  • Inflammation of the brain, spinal cord or bone marrow
  • Multiple sclerosis
  • Reye syndrome
  • Guillain-Barré syndrome
  • Neurosyphilis
  • Headaches of unknown cause

A lumbar puncture may be used to measure the pressure of the cerebrospinal fluid. Additionally, it may be performed to inject medications into the spinal canal. Spinal anesthesia, contrast dye for an X-ray exam or chemotherapy drugs are medications that may be given via a lumbar puncture.

For the procedure, the patient’s back is cleaned with an antibacterial solution. A doctor then administers a local anesthetic to numb the area. Next, the doctor inserts a hollow, thin needle into the lower back in the space between two vertebrae. The patient must stay completely still while the needle is inserted. He or she may feel some pressure. The cerebrospinal fluid is then removed through the needle. About a tablespoon of fluid is collected and sent to a lab for testing. After the fluid is collected, the patient may receive medication through the lumbar puncture.

The procedure takes about 30 minutes to perform.

Pap test and pelvic exam

A Pap test, or Pap smear, is a test forcervical canceror precancerous conditions of the cervix. The test is performed along with apelvic examin a doctor’s office or clinic.

For the test, a woman lies on an exam table with her knees bent and her feet in stirrups. A doctor or nurse practitioner then gently inserts a speculum and uses it to widen the patient’s vagina to examine the vagina and cervix. The doctor or nurse practitioner then obtains a sample of cells from the cervix, using a scraping tool or small brush. The sample is put into a small bottle or onto a slide and sent to a laboratory for analysis.

Pap tests take about five minutes to perform. Patients may experience slight discomfort and mild cramping.

Learn more aboutPap testsandpelvic exams

Learn more about cytology tests

Endoscopic procedures

Certain endoscopic procedures may be used to locate and diagnose cancer, particularly in the:

  • Esophagus
  • Colon
  • Rectum
  • Stomach
  • Chest

Anoscopy:This procedure is performed if abnormalities are found during a digital rectal exam (DRE). As anendoscopic test, an anoscopy reveals abnormalities through the use of a thin, lighted, flexible tube called an anoscope. The anoscope is lubricated and then placed a few inches into the rectum. The patient may experience some discomfort during the procedure. A tissue sample for a biopsy may be taken during an anoscopy. This diagnostic test helps to detect cancers of the anus or rectum. An anoscopy is similar to a colonoscopy, but a colonoscopy also examines the entire colon.

Esophagoscopy:This procedure involves the use of an esophagoscope, a thin tube with a lighted lens, to examine the esophagus. It may be used to help detectcancer of the esophagusas well as head andthroat cancers.

Mediastinoscopy:The area between your lungs and behind your breastbone is referred to as the mediastinum. During a mediastinoscopy, the doctor uses a lighted instrument with a lens, called a mediastinoscope, in order to view your chest cavity. This diagnostic procedure may help detect cancers of thelung,thymus glandand esophagus, as well aslymphomas. Biopsies of the lymph nodes may be taken as well.

Colonoscopy:This procedure allows the doctor to examine the inside of your colon, anus and rectum in order to detectcolon and rectal cancersin the early stages. A long, thin tube with a lighted lens is inserted into the rectum, and a biopsy of any suspicious areas may be taken.

Flexible sigmoidoscopy:我们像一个结肠镜检查,灵活的乙状结肠镜检查ed to detect colorectal cancers, but it’s a less invasive procedure that allows your doctor to view only about half of your colon. During a flexible sigmoidoscopy, a lighted tube is guided into the colon to help detect precancerous changes and abnormalities.

Learn more about endoscopic procedures

Pathology report

After a biopsy is collected, your tissue sample will be evaluated microscopically. These results—along with laboratory, imaging and other diagnostic testing—will be used to establish whether cancer is present, as well as the extent of the cancer, which helps determine treatment options.

Learn more about pathology reports

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